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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-BNS-22
BNS-22

Chemical Structure : BNS-22

CAS No.: 1151668-24-4‎

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BNS-22 (BNS22)

货号: PC-62442Not For Human Use, Lab Use Only.

BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively.
    BNS-22 does not affect DNA damage and antagonizes TOP2 poison-mediated DNA damage.
    BNS-22 induces mitotic abnormalities, causes polyploidy in HeLa cells.

    物理化学性质&存储条件

    分子量 407.466
    分子式 C24H25NO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-[(3,4-Dihydro-2H-quinolin-1-yl)carbonyl]-5,7-dimethoxy-4-propyl-2H-chromen-2-one

    参考文献

    1. Kawatani M, et al. Chem Biol. 2011 Jun 24;18(6):743-51.

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