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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-Indimitecan
Indimitecan

Chemical Structure : Indimitecan

CAS No.: 915360-05-3

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Indimitecan (LMP776;LMP-776;NSC 725776)

货号: PC-63535Not For Human Use, Lab Use Only.

Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor, shows antiproliferative activities against various human cancer cell lines.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor, shows antiproliferative activities against various human cancer cell lines.

物理化学性质&存储条件

分子量 459.458
分子式 C25H21N3O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-[3-(1H-Imidazol-1-yl)propyl]-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione

参考文献

1. Cinelli MA, et al. J Med Chem. 2012 Dec 27;55(24):10844-62.

2. Maede Y, et al. Mol Cancer Ther. 2014 Jan;13(1):214-20.

3. Beck DE, et al. J Med Chem. 2014 Feb 27;57(4):1495-512.

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