| Cat. No. |
Product Name |
Information |
| PC-20740 |
DKR-1677
σ2R/TMEM97 modulator
|
DKR-1677 (DKR1677) is a potent, selective σ2R/TMEM97 modulator with Ki value of 5.1 nM, 45-fold selectivity over σ1R (Ki=230 nM). |
| PC-20739 |
FEM-1689
σ2R/TMEM97 ligand
|
FEM-1689 (FEM1689) is a potent, selective σ2R/TMEM97 binding ligand with Ki value of 11 nM. |
| PC-49695 |
JR1-157
Sigma 2 receptor ligand
|
JR1-157 is a potent selective sigma 2 receptor (σ2R) ligand with Ki value of 47 nM, >10-fold selectivity over σ1R. |
| PC-49215 |
CT-189
Sigma 1 inhibitor
|
CT-189 (CT189) is a drug-like analog of IPAG and small-molecule Sigma1 receptor inhibitor, binds Sigma1 with Ki value of 38 nM in [3H](+)-pentazocine binding competition assays. |
| PC-47095 |
MAM03055A
Sigma 2 Receptor ligand
|
MAM03055A is a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity, exhibits high affinity and strong preference for sigma-2 receptor with Ki of 55.9 nM. |
| PC-38233 |
ANAVEX2-73
Sigma 1 receptor agonist
|
ANAVEX2-73 (Blarcamesine) hydrochloride is a potent Sigma-1 receptor agonist with IC50 of 860 nM, and muscarinic receptor modulator with neuroprotective effects. |
| PC-36088 |
Blarcamesine
Sigma 1 receptor agonist
|
ANAVEX2-73 (Blarcamesine) is a Sigma-1 receptor agonist with IC50 of 860 nM, and muscarinic receptor modulator with neuroprotective effects. |
| PC-35890 |
SN79 dihydrochloride
Sigma receptor antagonist
|
SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative sigma receptor (σ receptor) antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites. |
| PC-35305 |
BS148
Sigma 2 receptor agonist
|
BS148 (BS-148) is a potent, selective σ2 receptor agonist with pKi of 7.71, displays 25-fold selectivity over σ1. |
| PC-63494 |
JVW-1034
Sigma 2 Receptor ligand
|
JVW-1034 is a selective small molecule modulator of σ2R/Tmem97 with Ki of 23 nM, 10-fold weaker affinity for σ1R (Ki=248 nM). |
| PC-63432 |
Pridopidine
Sigma 1 receptor agonist
|
Pridopidine (ACR16, FR-310826, ASP-2314, Huntexil) is a selective and potent Sigma-1 receptor agonist. |
| PC-63205 |
MS-377
Sigma 1 receptor agonist
|
MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities. |
