CT-189 | Sigma 1 inhibitor | Probechem Biochemicals

Chemical Structure : CT-189

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CT-189 (CT189)

货号: PC-49215Not For Human Use, Lab Use Only.

CT-189 (CT189) is a drug-like analog of IPAG and small-molecule Sigma1 receptor inhibitor, binds Sigma1 with Ki value of 38 nM in [3H](+)-pentazocine binding competition assays.

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生物&药学活性

CT-189 (CT189) is a drug-like analog of IPAG and small-molecule Sigma1 receptor inhibitor, binds Sigma1 with Ki value of 38 nM in [3H](+)-pentazocine binding competition assays.
CT-189 inhibits androgen receptor (AR) transcriptional activity and AR splice variant (ARV) signaling, decreases KLK3/PSA mRNA transcript levels in LNCaP cells and 22Rv1 cells, decreases levels of ARV7 as well as AR protein levels.
CT-189 prevents 5α-dihydrotestosterone (DHT)-mediated nuclear translocation of AR and induced proteasomal degradation of AR and ARV, suppressing the transcriptional activity and protein levels of both full-length and splice-variant AR.
CT-189 (30 mg/kg, oral gavage) inhibits the growth of xenografted 22Rv1 tumors by 60% following -36 days of treatment.

物理化学性质&存储条件

分子量	321.780
分子式	C16H17ClFN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-chlorophenyl)-3-(3-(4-fluorophenoxy)propyl)guanidine

参考文献

1. Jeffrey D. Thomas, et al. Cancer Res. 2017 May 1; 77(9): 2439–2452.

CT-189 (CT189)

生物&药学活性

物理化学性质&存储条件

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CT-189 (CT189)

生物&药学活性

物理化学性质&存储条件

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