PB221 | Sigma-2 receptor agonist | Probechem Biochemicals

Chemical Structure : PB221

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PB221 (PB-221)

货号: PC-27723Not For Human Use, Lab Use Only.

PB221 is a selective sigma-2 receptor (σ2R/TMEM97) agonist with Ki of 18.8 nM, shows potent cytotoxic activity against neuroblastoma SK-N-SH cells with IC50 of 3.64 uM.

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生物&药学活性

PB221 is a selective sigma-2 receptor (σ2R/TMEM97) agonist with Ki of 18.8 nM, shows potent cytotoxic activity against neuroblastoma SK-N-SH cells with IC50 of 3.64 uM.
PB221 has IC50 of PB221 for ALTS1C1 and UN-KC6141 cell lines was 10.61 and 13.13 μM, respectively.
PB221 (1 μM) significantly repressed the migration and invasion of ALTS1C1 cells, and a high dose of PB221 (20 μM) resulted in the apoptotic cell death of ALTS1C1 cells.
PB221 effectively retarded tumor growth to 36% of the control tumor volume in the ectopic intramuscular tumor model.

物理化学性质&存储条件

分子量	369.59
分子式	C25H39NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-cyclohexyl-1-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl)piperidine

参考文献

1. Berardi F, et al. J Med Chem. 2009;52(23):7817–7828.

2. Liu CC, et al. BMC Cancer. 2026 Aug 14;26(1):985.

PB221 (PB-221)

生物&药学活性

物理化学性质&存储条件

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PB221 (PB-221)

生物&药学活性

物理化学性质&存储条件

参考文献

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