DKR-1677 | σ2R/TMEM97 modulator | Probechem Biochemicals

Chemical Structure : DKR-1677

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DKR-1677 (DKR1677)

货号: PC-20740Not For Human Use, Lab Use Only.

DKR-1677 (DKR1677) is a potent, selective σ2R/TMEM97 modulator with Ki value of 5.1 nM, 45-fold selectivity over σ1R (Ki=230 nM).

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生物&药学活性

DKR-1677 (DKR1677) is a potent, selective σ2R/TMEM97 modulator with Ki value of 5.1 nM, 45-fold selectivity over σ1R (Ki=230 nM).
DKR-1677 generally exhibits greater than 100-fold selectivity against a panel of more than 50 proteins relevant to the central nervous system (CNS), with the exception of histamine-1 (20-fold) and the alpha-2A adrenergic (68-fold) receptors.
DKR-1677 is neuroprotective after blast-induced and controlled cortical impact (CCI) TBI in mice.
DKR-1677 decreases axonal degeneration after blast-induced TBI and enhances survival of cortical neurons and oligodendrocytes after CCI injury.
DKR-1677 preserves cognition in the Morris water maze after blast TBI.

物理化学性质&存储条件

分子量	419.57
分子式	C26H33N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl 8-(4-propylpiperazin-1-yl)-1,3,4,5-tetrahydro-2H-1,5-methanobenzo[c]azepine-2-carboxylate

参考文献

1. Vázquez-Rosa E, et al. ACS Chem Neurosci. 2019 Mar 20;10(3):1595-1602.

DKR-1677 (DKR1677)

生物&药学活性

物理化学性质&存储条件

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DKR-1677 (DKR1677)

生物&药学活性

物理化学性质&存储条件

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