FEM-1689 | σ2R/TMEM97 ligand | Probechem Biochemicals

Chemical Structure : FEM-1689

加入收藏

FEM-1689 (FEM1689)

货号: PC-20739Not For Human Use, Lab Use Only.

FEM-1689 (FEM1689) is a potent, selective σ2R/TMEM97 binding ligand with Ki value of 11 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

FEM-1689 (FEM1689) is a potent, selective σ2R/TMEM97 binding ligand with Ki value of 11 nM.
FEM-1689 is >100-fold more selective for σ2R/TMEM97 than 40 CNS proteins except for σ1R (19-fold) and norepinephrine transporter (NET; 37-fold).
FEM-1689 inhibits the integrated stress response and promotes neurite outgrowth via a σ2R/TMEM97-specific action in primary mouse dorsal root ganglion (DRG) neurons.
FEM-1689 reduces ISR and p-eIF2α levels in human sensory neurons and alleviates the pathogenic engagement of integrated stress response (ISR) by methylglyoxal.
FEM-1689 (10 mg/kg, i.v.) produced analgesic effect in mouse neuropathic pain models.

物理化学性质&存储条件

分子量	361.41
分子式	C21H22F3NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(8-(4-(trifluoromethyl)phenyl)-1,3,4,5-tetrahydro-2H-1,5-methanobenzo[c]azepin-2-yl)propan-1-ol

参考文献

1. Yousuf MS, et al. bioRxiv. 2023 Apr 11:2023.04.11.536439.

FEM-1689 (FEM1689)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

FEM-1689 (FEM1689)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.