| Cat. No. |
Product Name |
Information |
| PC-42070 |
4-IBP
Sigma receptor agonist
|
4-IBP is a highly potent sigma receptor agonist with Ki of 1.7 nM and 25.2 nM for σ1 and σ2, respectively. |
| PC-28289 |
Siramesine hydrochloride
Sigma-2 receptor agonist
|
Siramesine hydrochloride (Lu 28-179) is a lysosomotropic agent and potent, selective sigma-2 receptor ligand and agonist with binding IC50 of 0.12 nM, exhibits 140-fold selectivity over Sigma-1 receptor. |
| PC-28288 |
Siramesine
Sigma-2 receptor agonist
|
Siramesine (Lu 28-179) is a lysosomotropic agent and potent, selective sigma-2 receptor ligand and agonist with binding IC50 of 0.12 nM, exhibits 140-fold selectivity over Sigma-1 receptor. |
| PC-28286 |
SV119
Sigma-2 receptor ligand
|
SV119 is a high-affinity, specific small molecule Sigma-2 receptor (σ2R, σ2 receptor) ligand with Ki of 5.19 nM, has 273-fold selectivity over σ1R. |
| PC-27163 |
LMH-2
Sigma-1 receptor antagonist
|
LMH-2 is a potent, selective sigma-1 receptor (σ1 R) antagonist with Ki of 6.0 nM, shows high σ1R/σ2R selectivity ratio, displays antihyperalgesic and antiallodynic effects. |
| PC-27162 |
BMY-14802 hydrochloride
Sigma-1 antagonist
|
BMY-14802 hydrochloride is a potent sigma-1 receptor (σ1R) antagonist with IC50 of 112 nM, also an agonist at serotonin 5-HT1A (IC50=320 nM) and adrenergic α-1 receptor (IC50=460 nM). |
| PC-27161 |
BMY-14802
Sigma-1 antagonist
|
BMY-14802 is a potent sigma-1 receptor (σ1R) antagonist with IC50 of 112 nM, also an agonist at serotonin 5-HT1A (IC50=320 nM) and adrenergic α-1 receptor (IC50=460 nM). |
| PC-27153 |
Dicloperidine
Sigma-1 receptor antagonist
|
Dicloperidine is a potent, selective sigma-1 receptor (σ1R) antagonist with Ki of 2.6 nM. |
| PC-26651 |
RC-106
Sigma receptor modulator
|
RC-106 is a high affinity, brain-penetrant, pan-sigma receptor modulator with Ki of 12.0 nM and 22.0 nM for S1R and S2R respectively. |
| PC-25927 |
SKF83959 hydrobromide
Sigma-1 receptor PAM
|
SKF83959 hydrobromide is a potent and selective dopamine D1-like receptor partial agonist with binding Ki of 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively, also is a potent allosteric modulator of Sigma 1 receptor (S1R), shows anti-seizure activities. |
| PC-25926 |
SKF83959
Sigma-1 receptor PAM
|
SKF83959 is a potent and selective dopamine D1-like receptor partial agonist with binding Ki of 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively, also is a potent allosteric modulator of Sigma 1 receptor (S1R), shows anti-seizure activities. |
| PC-24306 |
CM699
DAT/σ1R antagonist
|
CM699 isa dual-action compound with σ1R antagonist effects and affinity for the DAT with Ki of 311 and 14.1 nM at DAT and σ1Rs, respectively, inhibits DA uptake ex vivo. |
