| Cat. No. |
Product Name |
Information |
| PC-49646 |
SMN antagonist 1
SMN inhibitor
|
SMN antagonist 1 (Compound 1) is a small molecule antagonist of Survival of motor neuron (SMN), preferentially binds to SMN (Kd=2.6 uM) among assayed methylarginine or methyllysine binders, disrupts the SMN-RNAP II interaction. |
| PC-72088 |
SMN2 splicing modulator TEC-1
SMN2 splicing modulator
|
SMN2 splicing modulator TEC-1 is a novel specific, CNS penetrant small molecule SMN2 splicing modulator, increases the expression level of FL-SMN2 mRNA and decreases the expression level of Δ7 mRNA. |
| PC-35177 |
PK4C9
SMN2 splicing modulator
|
PK4C9 (Homocarbonyltopsentin) is a small-molecule stem-loop RNA structure TSL2-binding compound (EC50=16.1 uM) that increases SMN2 exon 7 (E7) splicing and rescues downstream molecular alterations in SMA cells. |
| PC-63445 |
SMN-C3-1
SMN2 splicing modulator
|
SMN-C3 is a close analogs of RG7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing, modulates SMN2 alternative splicing and increases SMN protein levels. |
| PC-63444 |
SMN-C2
SMN2 splicing modulator
|
SMN-C2 is a close analogs of RG-7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing, modulates SMN2 alternative splicing and increases SMN protein levels. |
| PC-62675 |
SMN-C3
SMN2 splicing modulator
|
SMN-C3 is a selective, orally available small molecule SMN2 splicing modifier toward the production of full-length SMN2 messenger RNA with high selectivity. |
| PC-62370 |
Cuspin-1
SMN2 splicing modulator
|
Cuspin-1 is a small molecule upregulator of SMN (Survival of Motor Neuron protein) with EC50 of 18 uM. |
| PC-62139 |
ML372
SMN modulator
|
ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM. |
| PC-61637 |
LDN-109657
SMN2 modulator
|
LDN-109657 is a novel SMN2 modulator that increase SMN protein levels in 3813 fibroblasts by twofold at 370 nM. |
| PC-61636 |
LDN-75654
SMN2 modulator
|
LDN-75654 is a novel potent SMN2 modulator (EC50=1.8 uM, Emax 186%), increases SMN protein in spinal cord and brain in mice. |
| PC-61635 |
LDN-76070
SMN2 modulator
|
LDN-76070 is a novel potent SMN2 modulator (EC50=8.3 uM, Emax 186%), increases SMN protein in spinal cord and brain in mice (5 mg/kg). |
| PC-61634 |
SMN2 modulator 27
SMN2 modulator
|
SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM. |
