SMN2 modulator 27 |CAS:1537150-15-4 Probechem Biochemicals

Chemical Structure : SMN2 modulator 27

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SMN2 modulator 27

货号: PC-61634Not For Human Use, Lab Use Only.

SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM.
SMN2 modulator 27 shows excellent in vitro properties and a promising mouse PK profile, stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition.
SMN2 modulator 27 shows a novel therapeutic mechanism that should complement other modalities for treatment of SMA.

物理化学性质&存储条件

分子量	326.77
分子式	C14H12ClFN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Chloro-4-fluoro-N-(5-(1-hydroxycyclobutyl)thiazol-2-yl)benzamide

参考文献

1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610.