ML372 | SMN modulator | Probechem Biochemicals

Chemical Structure : ML372

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ML372 (ML 372)

货号: PC-62139Not For Human Use, Lab Use Only.

ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM.

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100 mg		Get quote

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生物&药学活性

ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM.
ML372 possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo.
ML372 restores motor function, and prolong survival of SMNΔ7 SMA Mice, improves the righting reflex and extended survival of a severe mouse model of SMA.

物理化学性质&存储条件

分子量	360.428
分子式	C18H20N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)thiazol-2-yl)piperidine-4-carboxylic acid

参考文献

1. Burnett BG, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Abera MB, et al. JCI Insight. 2016 Nov 17;1(19):e88427.

ML372 (ML 372)

生物&药学活性

物理化学性质&存储条件

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ML372 (ML 372)

生物&药学活性

物理化学性质&存储条件

参考文献

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