SMN antagonist 1 | SMN inhibitor | Probechem Biochemicals

Chemical Structure : SMN antagonist 1

CAS No.: 445463-11-6

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SMN antagonist 1 (SMN inhibitor)

货号: PC-49646Not For Human Use, Lab Use Only.

SMN antagonist 1 (Compound 1) is a small molecule antagonist of Survival of motor neuron (SMN), preferentially binds to SMN (Kd=2.6 uM) among assayed methylarginine or methyllysine binders, disrupts the SMN-RNAP II interaction.

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生物&药学活性

SMN antagonist 1 (Compound 1) is a small molecule antagonist of Survival of motor neuron (SMN), preferentially binds to SMN (Kd=2.6 uM) among assayed methylarginine or methyllysine binders, disrupts the SMN-RNAP II interaction.
SMN antagonist 1 binds tighly to methylarginine binding Tudor domains of SMN, SMNDC1, and TDRD3 than to the methyllysine binding Tudor domain of UHRF1_TTD (Kd=16 uM).
SMN antagonist 1 binds to the aromatic cage of SMN specifically.
SMN antagonist 1 disrupts SMN gene occupancy and lead to RNAP II pause, causes R-loop accumulation in HEK293 cells as detected by immunofluorescence staining.

物理化学性质&存储条件

分子量	188.27
分子式	C12H16N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine

参考文献

1. Liu Y, et al. Nat Commun. 2022 Sep 16;13(1):5453.

SMN antagonist 1 (SMN inhibitor)

生物&药学活性

物理化学性质&存储条件

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SMN antagonist 1 (SMN inhibitor)

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