PK4C9 (Homocarbonyltopsentin)

Chemical Structure : PK4C9

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货号: PC-35177Not For Human Use, Lab Use Only.

PK4C9 (Homocarbonyltopsentin) is a small-molecule stem-loop RNA structure TSL2-binding compound (EC50=16.1 uM) that increases SMN2 exon 7 (E7) splicing and rescues downstream molecular alterations in SMA cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PK4C9 (Homocarbonyltopsentin) is a small-molecule stem-loop RNA structure TSL2-binding compound (EC50=16.1 uM) that increases SMN2 exon 7 (E7) splicing and rescues downstream molecular alterations in SMA cells.
PK4C9 modifies SMN2 E7 splicing in different systems, rescues functional SMN protein in SMA cells.

物理化学性质&存储条件

分子量	370.368
分子式	C21H14N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-(1H-indole-3-carbonyl)-1H-imidazol-2-yl)(6-hydroxy-1H-indol-3-yl)methanone

参考文献

1. Garcia-Lopez A, et al. Nat Commun. 2018 May 23;9(1):2032.