SMN-C3-1 |SMN2 splicing modulator Probechem Biochemicals

Chemical Structure : SMN-C3-1

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SMN-C3-1 (SMN2 splicing modulator)

货号: PC-63445Not For Human Use, Lab Use Only.

SMN-C3 is a close analogs of RG7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing, modulates SMN2 alternative splicing and increases SMN protein levels.

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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SMN-C3-1 is a close analogs of RG7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing, modulates SMN2 alternative splicing and increases SMN protein levels.
SMN-C3 directly binds to the AGGAAG motif on exon 7 of the SMN2 pre-mRNA, and promotes a conformational change in two to three unpaired nucleotides at the junction of intron 6 and exon 7 in both in vitro and in-cell models.
SMN-C3 increases binding of the splicing modulators, far upstream element binding protein 1 (FUBP1) and its homolog, KH-type splicing regulatory protein (KHSRP), to the SMN-C2/C3-SMN2 pre-mRNA complex and enhances SMN2 splicing.

物理化学性质&存储条件

分子量	417.517
分子式	C23H27N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4,6-dimethylpyrazolo[1,5-a]pyrazin-2-yl)-7-(4-ethylpiperazin-1-yl)-9-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

参考文献

1. Wang J, et al. Proc Natl Acad Sci U S A. 2018 Apr 30. pii: 201800260.