LDN-76070 | SMN2 modulator | Probechem Biochemicals

Chemical Structure : LDN-76070

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货号: PC-61635Not For Human Use, Lab Use Only.

LDN-76070 is a novel potent SMN2 modulator (EC50=8.3 uM, Emax 186%), increases SMN protein in spinal cord and brain in mice (5 mg/kg).

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LDN-76070 is a novel potent SMN2 modulator (EC50=8.3 uM, Emax 186%), increases SMN protein in spinal cord and brain in mice (5 mg/kg).

分子量	410.239
分子式	C18H17BrFNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-bromo-2-fluorophenyl)-5,6,7-trimethoxy-3,4-dihydroquinolin-2(1H)-one

1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610.

2. Cherry JJ, et al. EMBO Mol Med. 2013 Jul;5(7):1103-18.