| Cat. No. |
Product Name |
Information |
| PC-63169 |
PF-06815345
PCSK9 inhibitor
|
PF-06815345 (PF-6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay. |
| PC-60376 |
R-IMPP
PCSK9 secretion inhibitor
|
R-IMPP ((R)-IMPP, PF-00932239) is a small molecule inhibitor of PCSK9 secretion (IC50=4.8 uM) that selectively binds to human 80S ribosome, but not E. coli, ribosomes. |
| PC-70150 |
PF-06446846 hydrochloride
PCSK9 inhibitor
|
PF-06446846 hydrochloride (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells. |
| PC-70149 |
PF-06446846
PCSK9 inhibitor
|
PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells. |
| PC-26864 |
CVI-LM001
PCSK9 inhibitor
|
CVI-LM001 is a fluorobenzenesulfonate derivative of corydaline acting by suppressing the expression of PCSK9 gene and by stabilizing LDL mRNA, increases the LDL receptor levels by both inhibiting PCSK9 transcription and preventing LDL receptor mRNA degradation. |
| PC-26863 |
PF-06815345 hydrochloride
PCSK9 inhibitor
|
PF-06815345 hydrochloride (PF-6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay. |
| PC-26862 |
DC371739
HNF-1α inhibitor, PCSK9 inhibitor
|
DC371739 is a lipid-lowering small compound that directly binds to HNF-1α with Kd of 2.3 uM in BLI assays and inhibit its dimerization, inhibits the transcription levels of both PCSK9 and ANGPTL3, displays promising hypolipidemic effects both in vitro and in vivo. |
| PC-26305 |
Enlicitide decanoate
PCSK9 inhibitor
|
Enlicitide decanoate (MK-0616) is a highly potent, orally bioavailable macrocyclic peptide inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with Ki of 5 pM, binds to the LDLR binding domain of PCSK9. |
| PC-25615 |
PCSK9 inhibitor Pep2-8
PCSK9 inhibitor
|
Pep2-8 is a specific small peptide PCSK9 inhibitor with a binding KD of 0.7 μM, inhibits LDL receptor and EGF(A) domain binding to PCSK9 with IC50 values of 0.8 μMand 0.4 μM respectively, Pep2-8 is an EGF(A)-mimicking peptide and does not bind to other proprotein convertases. |
| PC-25140 |
Inclisiran
PCSK9 inhibitor
|
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibit the transcription of PCSK9, inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18, shows anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. |
| PC-24901 |
Pinostrobin
PCSK9 inhibitor
|
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities, Pinostrobin is a potent PCSK9 inhibitor, inhibits PCSK9 promoter activity as well as the suppression of PCSK9 mRNA expression in HepG2 cells. |
| PC-24178 |
PCSK9 inhibitor 3f
PCSK9 inhibitor
|
PCSK9 inhibitor 3f is a small molecule, orally bioavailable inhibitor of PCSK9 that antagonizes PCSK9-LDLR interaction with IC50 of 537 nM. |
