PCSK9 inhibitor 3f

Chemical Structure : PCSK9 inhibitor 3f

CAS No.: 2244129-23-3

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货号: PC-24178Not For Human Use, Lab Use Only.

PCSK9 inhibitor 3f is a small molecule, orally bioavailable inhibitor of PCSK9 that antagonizes PCSK9-LDLR interaction with IC50 of 537 nM.

规格	价格	库存
2 mg	￥1580	In stock
5 mg	￥2580	In stock
10 mg	￥4280	In stock
25 mg	￥7280	In stock
50 mg		Get quote

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生物&药学活性

PCSK9 inhibitor 3f is a small molecule, orally bioavailable inhibitor of PCSK9 that antagonizes PCSK9-LDLR interaction with IC50 of 537 nM.
PCSK9 inhibitor 3f shows no inhibitory activity (IC50 > 10 µM) against a small panel of kinases.
PCSK9 inhibitor 3f restored LDL uptake by liver cells at sub-micromolar levels and demonstrated excellent bioavailability when delivered subcutaneously in mice.
PCSK9 inhibitor 3f lowered total cholesterol levels in the plasma of wild-type mice.

物理化学性质&存储条件

分子量	495.63
分子式	C30H33N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(3-((3-aminopiperidin-1-yl)methyl)-5-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methyl-3-phenoxybenzamide

参考文献

1. Evison BJ, et al. Bioorg Med Chem. 2020 Mar 15;28(6):115344.