R-IMPP (PF-00932239) | PCSK9 secretion inhibitor | Probechem Biochemicals

Chemical Structure : R-IMPP

CAS No.: 2133832-83-2

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R-IMPP ((R)-IMPP, PF-00932239)

货号: PC-60376Not For Human Use, Lab Use Only.

R-IMPP ((R)-IMPP, PF-00932239) is a small molecule inhibitor of PCSK9 secretion (IC50=4.8 uM) that selectively binds to human 80S ribosome, but not E. coli, ribosomes.

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10 mg	￥1980	In stock
25 mg	￥3580	In stock
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生物&药学活性

R-IMPP ((R)-IMPP, PF-00932239) is a small molecule inhibitor of PCSK9 secretion (IC50=4.8 uM) that selectively binds to human 80S ribosome, but not E. coli, ribosomes.
R-IMPP causes transcript-dependent inhibition of PCSK9 translation, stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.

物理化学性质&存储条件

分子量	389.5
分子式	C24H27N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide

参考文献

1. Petersen DN, et al. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371.

R-IMPP ((R)-IMPP, PF-00932239)

生物&药学活性

物理化学性质&存储条件

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R-IMPP ((R)-IMPP, PF-00932239)

生物&药学活性

物理化学性质&存储条件

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