PF-06815345 hydrochloride

Chemical Structure : PF-06815345 hydrochloride

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货号: PC-26863Not For Human Use, Lab Use Only.

PF-06815345 hydrochloride (PF-6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PF-06815345 hydrochloride (PF-6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay.
PF-06815345 is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1).

物理化学性质&存储条件

分子量	634.49
分子式	C27H30Cl2FN9O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(5-(4-(4-((3-chloropyridin-2-yl)((R)-piperidin-3-yl)carbamoyl)-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)-1H-tetrazol-1-yl)ethyl ethyl carbonate hydrochloride

参考文献

1. McClure KF, et al. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16218-16222.

2. Daniel Pettersen, et al. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.