PF-06446846 hydrochloride (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells.
PF-06446846 hydrochloride (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells.
PF-06446846 shows no general effect on the secreted and intracellular proteome.
PF-06446846 induces the ribosome to stall around codon 34, mediated by the sequence of the nascent chain within the exit tunnel.
PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.
