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首页-小分子抑制剂&激动剂-Others-PCSK9-DC371739
DC371739

Chemical Structure : DC371739

CAS No.: 2135765-21-6

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DC371739 (DC-371739)

货号: PC-26862Not For Human Use, Lab Use Only.

DC371739 is a lipid-lowering small compound that directly binds to HNF-1α with Kd of 2.3 uM in BLI assays and inhibit its dimerization, inhibits the transcription levels of both PCSK9 and ANGPTL3, displays promising hypolipidemic effects both in vitro and in vivo.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DC371739 is a lipid-lowering small compound that directly binds to HNF-1α with Kd of 2.3 uM in BLI assays and inhibit its dimerization, inhibits the transcription levels of both PCSK9 and ANGPTL3, displays promising hypolipidemic effects both in vitro and in vivo.
DC371739 interferes with the transcriptional function of HNF-1α by disrupting its binding to DNA.
DC371739 also inhibits HNF-1α target genes such as Dedicator of cytokinesis protein 3 (Dock3) and Zinc finger and BTB domain-containing protein 20 (Zbtb20).
DC371739 downregulates PCSK9 expression and upregulates LDLR expression both in vitro and in vivo.
DC371739 inhibits ANGPTL3 expression and enhances lipoprotein lipase activity both in vitro and in vivo.
Combination of DC371739 and atorvastatin shows an additive effect in lipid clearance both in vitro and in vivo.
DC371739 significantly decreases serum TC, LDL-C, and TG levels simultaneously in HFD-fed hamsters, and decreases serum TC and LDL-C levels in spontaneous hyperlipidemic rhesus monkeys and individuals with hypercholesterolemia.

物理化学性质&存储条件

分子量 470.57
分子式 C29H30N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3-(Benzyloxy)-2,12-dimethoxy-5,8,14,14a-tetrahydroindolo[3',2':4,5]pyrido[2,1-a]isoquinolin-9(6H)-yl)methanol

参考文献

1. Wang J, et al. Cell Metab. 2022 May 3;34(5):667-680.e6.

2. Masson W, Adv Ther. 2026 Jan;43(1):304-316.

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