PF-06446846 |CAS 1632250-49-7 Buy PF-06446846 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : PF-06446846

CAS No.: 1632250-49-7

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PF-06446846 (PF-6446846;PF 06446846)

货号: PC-70149Not For Human Use, Lab Use Only.

PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells.

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5 mg	￥1980	In stock
25 mg	￥3980	In stock
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1 g		Get quote

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生物&药学活性

PF-06446846 (PF-6446846) is a potent, highly selective inhibitor of PCSK9 translation with IC50 of 0.3 uM for inhibition the secretion of PCSK9 by Huh7 cells.
PF-06446846 shows no general effect on the secreted and intracellular proteome.
PF-06446846 induces the ribosome to stall around codon 34, mediated by the sequence of the nascent chain within the exit tunnel; reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.

物理化学性质&存储条件

分子量	433.9
分子式	C22H20ClN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide

参考文献

1. Lintner NG, et al. PLoS Biol. 2017 Mar 21;15(3):e2001882.

PF-06446846 (PF-6446846;PF 06446846)

生物&药学活性

物理化学性质&存储条件

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PF-06446846 (PF-6446846;PF 06446846)

生物&药学活性

物理化学性质&存储条件

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