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首页-小分子抑制剂&激动剂-Others-PCSK9-SBC-115076
SBC-115076

Chemical Structure : SBC-115076

CAS No.: 489415-96-5

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SBC-115076 (SBC115076)

货号: PC-63171Not For Human Use, Lab Use Only.

SBC-115076 is a PCSK9 inhibitor that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SBC-115076 is a PCSK9 inhibitor that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations.
SBC-115076 effectively lowers cholesterol levels in high fat diet mice.

物理化学性质&存储条件

分子量 527.621
分子式 C31H33N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1,5-dihydro-2H-pyrrol-2-one

参考文献

1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.

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