| Cat. No. |
Product Name |
Information |
| PC-72721 |
5-BDBD
P2X4 antagonist
|
5-BDBD is a potent and selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4-mediated currents in CHO cells with IC50 of 0.5 uM. |
| PC-72666 |
Sivopixant
P2X3 antagonist
|
Sivopixant (S-600918) is a potent and selective P2X3 homotrimers antagonist with IC50 of 4.2 nM, 250-fold selectivity over P2X2/3 heterotrimer (IC50=1,100 nM). |
| PC-72592 |
HEI3090
P2X7R activator
|
HEI3090 (HEI-3090) is a small-molecule P2RX7 activator (positive modulator) of purinergic P2RX7 receptor (P2X7R), enhances the P2RX7-mediated intracellular calcium concentration (Emax=250 nM). |
| PC-38015 |
Lu AF27139
P2X7 antagonist
|
Lu AF27139 is a potent, selective, CNS-penetrant P2X7 receptor antagonist, inhibits BzATP-induced currents in rat primary microglia with IC50 of 66 nM. |
| PC-63496 |
AZ-2
ABCA1/apoE inducer
|
AZ-2 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity. |
| PC-63495 |
AZ-1
ABCA1/apoE inducer
|
AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity. |
| PC-63426 |
AZ10606120 dihydrochloride
P2X7 antagonist
|
AZ10606120 dihydrochloride is a potent, specific P2X7 receptor antagonist with Kd of 1.4 and 19 nM at human and rat P2X7 receptors respectively. |
| PC-63425 |
JNJ-47965567
P2X7 antagonist
|
JNJ-47965567 is a potent, selective, centrally permeable P2X7 receptor antagonist with pKi of 7.9 and 8.7 for human and rat P2X7, respectively. |
| PC-63353 |
MK-3901
P2X3 antagonist
|
MK-3901 is a potent, selective, orally active P2X3 antagonist with IC50 of 21 nM. |
| PC-62763 |
JNJ-55308942
P2X7 antagonist
|
Zanvipixant (JNJ-55308942) is a highly potent, selective, brain-penetrant P2X7 antagonist with Ki of 1.0 and 6.5 nM for rat and human hP2X7. |
| PC-62755 |
RO-51
P2X3 antagonist
|
RO-51 is a potent, selective and drug-like dual P2X3 and P2X2/3 antagonist with pIC50 of 8.7 and 8.3, respectively. |
| PC-62754 |
AF-353
P2X3 antagonist
|
AF-353 (RO-4) is a potent, selective and drug-like dual P2X3 and P2X2/3 antagonist with pIC50 of 8.0 and 7.1, respectively. |
