Eliapixant (BAY 1817080) | P2X3 antagonist | Probechem Biochemicals

Chemical Structure : Eliapixant

CAS No.: 1948229-21-7

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Eliapixant (BAY 1817080, BAY1817080)

货号: PC-72754Not For Human Use, Lab Use Only.

Eliapixant (BAY 1817080) is a potent, selective P2X3 receptor antagonist with IC50 of 8 nM (hP2X3).

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Eliapixant (BAY 1817080) is a potent, selective P2X3 receptor antagonist with IC50 of 8 nM (hP2X3).
Eliapixant inhibits agonist-mediated hP2X2/3 receptor response, show no inhibition on recombinant cell lines expressing hP2X1 receptors, and the homotrimeric hP2X2, hP2X4, and hP2X7 receptors.
Eliapixant reduces inflammatory pain in relevant animal models, and reduces vaginal hyperalgesia in an animal model of endometriosis-associated dyspareunia, even beyond treatment cessation.

物理化学性质&存储条件

分子量	478.49
分子式	C22H21F3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 3-(5-methyl-2-thiazolyl)-5-[[(3R)-tetrahydro-3-furanyl]oxy]-N-[(1R)-1-[2-(trifluoromethyl)-5-pyrimidinyl]ethyl]-

参考文献

1. Davenport AJ, et al. Sci Rep. 2021 Oct 6;11(1):19877.

2. Morice A, et al. Eur Respir J. 2021 Nov 18;58(5):2004240.

Eliapixant (BAY 1817080, BAY1817080)

生物&药学活性

物理化学性质&存储条件

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Eliapixant (BAY 1817080, BAY1817080)

生物&药学活性

物理化学性质&存储条件

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