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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-BAY-1797
BAY-1797

Chemical Structure : BAY-1797

CAS No.: 2055602-83-8

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BAY-1797 (BAY1797)

货号: PC-73112Not For Human Use, Lab Use Only.

BAY-1797 (BAY1797) is a potent and selective P2X4 inhibitor/antagonist with IC50 of 211 nM (hP2X4).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY-1797 (BAY1797) is a potent and selective P2X4 inhibitor/antagonist with IC50 of 211 nM (hP2X4).
BAY-1797 is suitable for in vivo studies in rodents.
BAY-1797 demonstrated anti-inflammatory and anti-nociceptive effects in a mouse complete Freund's adjuvant (CFA) inflammatory pain model.
BAY-1797 displays no or very weak activity on the other P2X ion channels (humanP2X1, P2X23, P2X3, P2X7, all IC50 >8.3 uM), does not inhibit hERG and Carbonic Anhydrase II, also is selective against a panel of off-targets, including GPCRs, ion channels, kinases, and transporters at 10 uM.

物理化学性质&存储条件

分子量 416.876
分子式 C20H17ClN2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(3-Chlorophenoxy)-3-sulfamoylphenyl)-2-phenylacetamide

参考文献

1. Werner S, et al. J Med Chem. 2019 Dec 26;62(24):11194-11217.

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