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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-A438079
A438079

Chemical Structure : A438079

CAS No.: 899507-36-9

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A438079 (A 438079)

货号: PC-21903Not For Human Use, Lab Use Only.

A438079 is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg ￥3980 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A438079 is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line.
A438079 hows little to no activity at other P2 receptors (IC50 > 10 μM).
A438079 inhibits methamphetamine-induced microglial migration and phagocytosis in vitro.
A438079 possesses antinociceptive activity in models of neuropathic pain in vivo.

物理化学性质&存储条件

分子量 306.15
分子式 C13H9Cl2N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine

参考文献

1. Tsukimoto M, et al. Biochem Biophys Res Commun. 2009 Jul 10;384(4):512-8.

2. Nelson DW, et al. J Med Chem. 2006 Jun 15;49(12):3659-66. doi: 10.1021/jm051202e.

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