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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-Filapixant
Filapixant

Chemical Structure : Filapixant

CAS No.: 1948232-63-0

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Filapixant (BAY1902607, BAY 1902607)

货号: PC-20738Not For Human Use, Lab Use Only.

Filapixant (BAY1902607) is a potent, selective P2X3 receptor antagonist, shows a substantially higher in vitro selectivity for P2X3 over P2X2 when compared with Eliapixant (BAY1817080, Cat# PC-72754).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Filapixant (BAY1902607) is a potent, selective P2X3 receptor antagonist, shows a substantially higher in vitro selectivity for P2X3 over P2X2 when compared with Eliapixant (BAY1817080, Cat# PC-72754).
Filapixant has a higher in vitro selectivity for P2X3 than other receptor antagonists such as gefapixant, or even eliapixant.

物理化学性质&存储条件

分子量 521.56
分子式 C24H26F3N5O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(N[C@@H](C1=CN=C(C(F)(F)F)N=C1)C)C2=CC(C3=NC=C(C)S3)=CC(OC[C@H]4CN(C)CCO4)=C2

参考文献

1. Davenport AJ, et, al. 1,3-thiazol-2-yl substituted benzamides. WO2016091776A1.

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