NF449 (NF449 octasodium) | P2X1 antagonist | Probechem Biochemicals

Chemical Structure : NF449

CAS No.: 627034-85-9

加入收藏

NF449 (NF-449, NF449 octasodium)

货号: PC-49765Not For Human Use, Lab Use Only.

NF449 (NF-449) is a highly potent, selective and reversible competitive human P2X1 receptor antagonist with IC50 of 0.05 nM.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NF449 (NF-449) is a highly potent, selective and reversible competitive human P2X1 receptor antagonist with IC50 of 0.05 nM.
NF449 antagonizes ATP or alphabeta-methyleneadenosine 5'-trisphosphate-induced inward currents of homomeric rat P2X(1)-P2X(4) receptors or heteromeric P2X(1 + 5) and P2X(2+3) receptors, respectively.
NF449 is less potent at homomeric P2X(2) receptors (IC(50) 47 microM) and homomeric P2X(4) receptors (IC(50) > 300 microM).

物理化学性质&存储条件

分子量	1505.05
分子式	C41H24N6Na8O29S8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 4,4',4'',4'''-((5,5'-(carbonylbis(azanediyl))bis(isophthaloyl))tetrakis(azanediyl))tetrakis(benzene-1,3-disulfonate)

参考文献

1. Hechler B, et al. J Pharmacol Exp Ther. 2005 Jul;314(1):232-43.

2. Kassack MU, et al. Eur J Med Chem. 2004 Apr;39(4):345-57.

3. Hülsmann M, et al. Eur J Pharmacol. 2003 May 30;470(1-2):1-7.

4. Suzuki E, et al. Mol Pharmacol. 2004 Dec;66(6):1738-47.

NF449 (NF-449, NF449 octasodium)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NF449 (NF-449, NF449 octasodium)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.