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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-Sivopixant
Sivopixant

Chemical Structure : Sivopixant

CAS No.: 2414285-40-6

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Sivopixant (S-600918, S600918)

货号: PC-72666Not For Human Use, Lab Use Only.

Sivopixant (S-600918) is a potent and selective P2X3 homotrimers antagonist with IC50 of 4.2 nM, 250-fold selectivity over P2X2/3 heterotrimer (IC50=1,100 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sivopixant (S-600918) is a potent and selective P2X3 homotrimers antagonist with IC50 of 4.2 nM, 250-fold selectivity over P2X2/3 heterotrimer (IC50=1,100 nM).
Sivopixant (S-600918) showed excellent profiles, potent analgesic effect, excellent absorbability and balanced PK profile.

物理化学性质&存储条件

分子量 507.931
分子式 C25H22ClN5O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S,E)-3-(3-(4-chlorobenzyl)-2,6-dioxo-4-((4-(pyridin-2-yloxy)phenyl)imino)-1,3,5-triazinan-1-yl)-2-methylpropanoic acid

参考文献

1. Hiroyuki Kai, et al. Bioorg Med Chem Lett. 2021 Nov 15;52:128384.

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