| Cat. No. |
Product Name |
Information |
| PC-45149 |
Gemcitabine
|
Gemcitabine (NSC 613327, LY188011) is a synthetic pyrimidine nucleoside prodrug that works by ihibiting the enzyme ribonucleotide reductase (RNR) and blocking the creation of new DNA. |
| PC-42402 |
MT-DADMe-ImmA
MTAP inhibitor
|
MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A, MTDIA) is a stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with dissociation constant of 86 pM. |
| PC-45630 |
Didox
Ribonucleotide reductase inhibitor
|
Didox is a ribonucleotide reductase (RNR) inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells, inhibits LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α. |
| PC-42711 |
Raltitrexed
Antifolate
|
Raltitrexed (ZD1694, D1694, ICI-D1694) is a quinazoline antifolate thymidylate synthase (TS) inhibitor with Ki of 62 nM. |
| PC-42266 |
Triapine
RRM2 inhibitor
|
Triapine (3-AP, PAN-811, OCX191, NSC 663249) is a potent inhibitor of ribonucleotide reductase subunit M2 (RRM2) with broad spectrum antitumor activity. |
| PC-42285 |
Acelarin
|
Acelarin (NUC-1031, CPF-31) is a gemcitabine phosphoramidate prodrug that can overcome the key cancer resistance |
| PC-45223 |
Tegafur
CAS 17902-23-7
|
Tegafur is a chemotherapeutic prodrug of 5-flourouracil (5-FU) used in the treatment of cancers, a thymidylate synthase inhibitor. |
| PC-42672 |
5-Azacytidine
DNA methyltransferase inhibitor
|
5-Azacytidine (5-AzaC, Azacitidine) is a chemical analog of Cytidine that inhibits DNA methyltransferase, induces mitochondrial apoptosis and autophagy. |
| PC-28223 |
Ribavirin
Antiviral guanosine analog
|
Ribavirin (Tribavirin, Ribasphere) is a synthetic guanosine analog with broad-spectrum of antiviral activity including HCV, HIV and RSV, inhibits the replication of RNA viruses such as flavi- and paramyxoviruses via inhibition of inosine monophosphate dehydrogenase enzyme (IMPDH), also inhibits viral RNA capping and the induces an error catastrophe. |
| PC-27576 |
TAS-102
Nucleoside Antimetabolite
|
TAS-102 (Trifluridine/tipiracil hydrochloride mixture) is a 1:0.5 mixture of alpha,alpha,alpha-trifluorothymidine (FTD) and 5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride thymidine phosphorylase inhibitor (TPI), inhibits thymidilate synthase (TS) and incorporation into DNA. |
| PC-27515 |
MB07133
Nucleoside analog
|
Zefoscytarabine (MB-7133, MB07133) is a liver-targeted prodrug of cytarabine mononucleotide (araCMP) and a DNA polymerase inhibitor inhibits DNA synthesis, selectively releases the monophosphate of a nucleoside (NMP) into CYP3A4-expressing cells, such as hepatocytes. |
| PC-27240 |
dCTPP1-IN-1
dCTPP1 inhibitor
|
dCTPP1-IN-1 is a potent, selective dCTP pyrophosphatase 1 (dCTPase, dCTPP1) inhibitor with IC50 of 36 nM, increases dCTPase thermal and protease stability, displays outstanding selectivity over related enzymes and synergizes with cytidine analogue against leukemic cells. |
