MT-DADMe-ImmA |CAS:653592-04-2 Probechem Biochemicals

Chemical Structure : MT-DADMe-ImmA

CAS No.: 653592-04-2

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MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A;MTDIA)

货号: PC-42402Not For Human Use, Lab Use Only.

A stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with dissociation constant of 86 pM.

规格	价格	库存
10 mg	￥1920	In stock
25 mg	￥3600	In stock
50 mg	￥6400	In stock
100 mg	￥11200	In stock
500 mg		Get quote

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生物&药学活性

A stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with dissociation constant of 86 pM; increases cellular 5'-methylthioadenosine (MTA) concentrations, decreases polyamines, and induces apoptosis in head and neck squamous cell carcinoma cell lines.

物理化学性质&存储条件

分子量	293.38786
分子式	C13H19N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO
Chemical Name/SMILES	3-Pyrrolidinol, 1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-, (3R,4S)-

参考文献

1. Basu I, et al. J Biol Chem. 2007 Jul 20;282(29):21477-86.

2. Guan R, et al. Biochemistry. 2013 Nov 19;52(46):8313-22.

3. Firestone RS, et al. ACS Chem Biol. 2017 Feb 17;12(2):464-473.

4. Singh V, et al. Biochemistry. 2004 Jan 13;43(1):9-18.

MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A;MTDIA)

生物&药学活性

物理化学性质&存储条件

参考文献

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MT-DADMe-ImmA (Methylthio-DADMe-Immucillin A;MTDIA)

生物&药学活性

物理化学性质&存储条件

参考文献

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