Didox | Ribonucleotide reductase inhibitor | Probechem Biochemicals

Chemical Structure : Didox

CAS No.: 69839-83-4

加入收藏

Didox (NSC 324360)

货号: PC-45630Not For Human Use, Lab Use Only.

Didox is a ribonucleotide reductase (RNR) inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells, inhibits LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Didox is a ribonucleotide reductase (RNR) inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells, inhibits LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α.
Didox induces apoptosis and inhibits DNA repair in multiple myeloma cells by downregulation of bcl family proteins including bcl-2, bcl(xl), and XIAP.
Didox (150 mg/kg daily) significantly protects the cardiomyocyte membrane integrity and decreases the intra-cardiac oxidative stress induced by DOX treatment (15 mg/kg) in mice.

物理化学性质&存储条件

分子量	169.1348
分子式	C7H7NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N,3,4-trihydroxy-

参考文献

1. Inayat MS, et al. Cancer Biol Ther. 2002 Sep-Oct;1(5):539-45.

2. Raje N, et al. Br J Haematol. 2006 Oct;135(1):52-61.

3. Al-Abd AM, et al. Eur J Pharmacol. 2013 Oct 15;718(1-3):361-9.

Didox (NSC 324360)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Didox (NSC 324360)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.