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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-Raltitrexed
Raltitrexed

Chemical Structure : Raltitrexed

CAS No.: 112887-68-0

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Raltitrexed (ZD1694;D1694;ICI-D1694)

货号: PC-42711Not For Human Use, Lab Use Only.

A quinazoline antifolate thymidylate synthase (TS) inhibitor with Ki of 62 nM.

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100 mg ￥3160 In stock
500 mg ￥8850 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A quinazoline antifolate thymidylate synthase (TS) inhibitor with Ki of 62 nM; inhibits TS with IC50 of 2.5 nM and L1210 tumor cell growth with IC50 of 8 nM; acitve in vivo.

Chemotherapeutic Agents

Approved

物理化学性质&存储条件

分子量 458.4876
分子式 C21H22N4O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 29 mg/mL
Chemical Name/SMILES

L-Glutamic acid, N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-

参考文献

1. Jackman AL, et al. Cancer Res. 1991 Oct 15;51(20):5579-86.

2. Yin MB, et al. Cancer Res. 1992 Nov 1;52(21):5900-5.

3. Pressacco J, et al. Cancer Res. 1995 Apr 1;55(7):1505-8.

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