| Cat. No. |
Product Name |
Information |
| PC-49549 |
NUC-7738
|
NUC-7738 is a ProTide and 5'-aryloxy phosphoramidate prodrug of 3'-Deoxyadenosine (3'-dA, Cordycepin), NUC-7738 is an effective anticancer drug in a panel of solid and hematological cancer cell lines. |
| PC-49421 |
Oroxylin A
Transketolase inhibitor
|
Oroxylin A is a small molecule transketolase (TKT) inhibitor with SPR KD of 70.7 uM, inhibits hepatocellular carcinoma growth in vitro and in vivo. |
| PC-49170 |
F-aza-T-dCyd
Cytidine analog
|
F-aza-T-dCyd (NSC801845) is a novel cytidine analog and is more efficacious than aza-T-dCyd in cell culture and mouse xenograft studies in HCT-116 human colon carcinoma. |
| PC-38899 |
TAS1553
Ribonucleotide reductase inhibitor
|
TAS1553 is a highly potent, selective small-molecule inhibitor of ribonucleotide reductase (RNR) with enzyme IC50 of 54.2 nM, binds to R1 subunit with Kd of 34.9 nM, disrupts PPI between R1 and R2 subunit. |
| PC-38835 |
DI-87
dCK inhibitor
|
DI-87 ((R)-DI-87, TRE-515) is a highly potent, specific, orally bioavailable deoxycytidine kinase (dCK) inhibitor with IC50 of 3.15 nM. |
| PC-38579 |
3-Deazauridine
CTP inhibitor
|
3-Deazauridine (DAU, NSC 126849) is a nucleoside analog that competitively inhibits cytidine triphosphate synthetase (CTP). |
| PC-38453 |
YMU1
hTMPK inhibitor
|
YMU1 is a specific, cell-permeable inhibitor of human thymidylate kinase (hTMPK) with IC50 of 0.61 uM in enzymatic assays. |
| PC-35966 |
Tipiracil hydrochloride
TPase inhibitor
|
Tipiracil hydrochloride (TPase inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibit uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase. |
| PC-35965 |
Thymidine Phosphorylase inhibitor 8g
|
Thymidine Phosphorylase inhibitor 8g (hTP inhibitor 8g) is a novel potent, selective inhibitor of human thymidine phosphorylase (hTP) with IC50 of 0.12 uM. |
| PC-35236 |
DFP-10917 hydrochloride
Deoxycytidine analog
|
DFP-10917 hydrochloride (CNDAC, TAS-109) is a deoxycytidine analog with antitumor activity against various tumor cells, is an orally available nucleoside analog prodrug of CNDAC. |
| PC-63498 |
TAS-114
dUTPase/DPD inhibitor
|
TAS-114 is a first-in-class, potent, dual dUTPase/DPD (dihydropyrimidine dehydrogenase) inhibitor with Ki of 0.13/2.14 uM, respectively. |
| PC-62751 |
5-NITP
Ribonucleotide reductase inhibitor
|
5-NITP is a non-natural nucleotide that inhibits ribonucleotide reductase (hRR) with IC50 of 170 uM, demonstrates anti-cancer effects against leukemia cells by altering cell-cycle progression. |
