3-Deazauridine | CTP inhibitor | Probechem Biochemicals

Chemical Structure : 3-Deazauridine

CAS No.: 23205-42-7

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3-Deazauridine (NSC 126849)

货号: PC-38579Not For Human Use, Lab Use Only.

3-Deazauridine (DAU, NSC 126849) is a nucleoside analog that competitively inhibits cytidine triphosphate synthetase (CTP).

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25 mg	￥880	In stock
100 mg	￥1580	In stock
250 mg	￥2580	In stock
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生物&药学活性

3-Deazauridine (DAU, NSC 126849) is a nucleoside analog that competitively inhibits cytidine triphosphate synthetase (CTP).
3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.
3-Deazauridine selectively suppresses cell viability in a MYC-dependent manner in ARPE-19 cells.
3-Deazauridine causes selective replication stress in MYC-overexpressing cells, which originates from MYC-driven rRNA synthesis.
3-Deazauridine combined with ATR inhibitor BAY-1895344 induces synthetic lethality to MYC-overexpressing cells, and suppresses tumor growth in 3D assays and in vivo.

物理化学性质&存储条件

分子量	243.21
分子式	C10H13NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxypyridin-2(1H)-on

参考文献

1. Bloch, A., et al. J. Med. Chem. 16(3), 294-297 (1973).

2. Zhe Sun, et al. Cancer Res. 2022 Mar 15;82(6):1013-1024.

3-Deazauridine (NSC 126849)

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3-Deazauridine (NSC 126849)

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