DI-87 (TRE-515) | dCK inhibitor | Probechem Biochemicals

Chemical Structure : DI-87

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DI-87 ((R)-DI-87, TRE-515)

货号: PC-38835Not For Human Use, Lab Use Only.

DI-87 ((R)-DI-87, TRE-515) is a highly potent, specific, orally bioavailable deoxycytidine kinase (dCK) inhibitor with IC50 of 3.15 nM.

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生物&药学活性

DI-87 ((R)-DI-87, TRE-515) is a highly potent, specific, orally bioavailable deoxycytidine kinase (dCK) inhibitor with IC50 of 3.15 nM.
(R)-DI-87 treatment rescued CEM cells from the anti-proliferative effects of gemcitabine, a dCK-dependent nucleoside analog prodrug, with an EC50 of 10.2 nM.
(R)-DI-87 is a promising new compound for use in combination therapy against tumors expressing dCK.

物理化学性质&存储条件

分子量	502.652
分子式	C23H30N6O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[(1R)-1-[2-[4-Methoxy-3-[2-(4-morpholinyl)ethoxy]phenyl]-5-methyl-4-thiazolyl]ethyl]thio]-4,6-pyrimidinediamine

参考文献

1. Soumya Poddar, et al. Biochem Pharmacol. 2020 Feb;172:113742.

DI-87 ((R)-DI-87, TRE-515)

生物&药学活性

物理化学性质&存储条件

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DI-87 ((R)-DI-87, TRE-515)

生物&药学活性

物理化学性质&存储条件

参考文献

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