欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-NUC-7738
NUC-7738

Chemical Structure : NUC-7738

CAS No.: 2348493-39-8

加入收藏

NUC-7738 (NUC7738)

货号: PC-49549Not For Human Use, Lab Use Only.

NUC-7738 is a ProTide and 5'-aryloxy phosphoramidate prodrug of 3'-Deoxyadenosine (3'-dA, Cordycepin), NUC-7738 is an effective anticancer drug in a panel of solid and hematological cancer cell lines.

规格 价格 库存 数量
5 mg Get quote
10 mg Get quote
25 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NUC-7738 is a ProTide and 5'-aryloxy phosphoramidate prodrug of 3'-Deoxyadenosine (3'-dA, Cordycepin), NUC-7738 is an effective anticancer drug in a panel of solid and hematological cancer cell lines.
    ProTide is comprised of a nucleoside fused to a protective phosphoramidate cap, NUC-7738 is capable of releasing active 3′-dAMP into cells where it is rapidly converted to the active species 3′-dATP.
    NUC-7738 also shows preferential cytotoxic effects on leukemic stem cells.
    Unlike 3'-dA, the activity of NUC-7738 is independent of hENT1 and kinase activity, NUC-7738 is resistant to ADA metabolic deactivation.
    NUC-7738 downregulate genes involved in cell survival (PI3K-AKT-MTOR, NOTCH, or WNT-Beta-Catenin Signaling), cell division (Mitotic Spindle, G2M Checkpoint), and DNA repair (UV-response_U or DNA Repair).
    NUC-7738 overcomes the cancer resistance mechanisms that limit the activity of 3'-dA.

    物理化学性质&存储条件

    分子量 568.527
    分子式 C26H29N6O7P
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    L-Alanine, N-(3′-deoxy-P-phenyl-5′-adenylyl)-, phenylmethyl ester

    参考文献

    1. Serpi M, et al. J Med Chem. 2022 Dec 8;65(23):15789-15804.

    2. Schwenzer H, et al. Clin Cancer Res. 2021 Dec 1;27(23):6500-6513.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: