dCK inhibitor DI-39

Chemical Structure : dCK inhibitor DI-39

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货号: PC-20182Not For Human Use, Lab Use Only.

DI-39 is a compound that inhibits the salvage pathways by blocking the enzyme, deoxycytidine kinase (dCK), induces replication stress in ALL cancer cell models through dCTP depletion.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DI-39 is a compound that inhibits the salvage pathways by blocking the enzyme, deoxycytidine kinase (dCK), induces replication stress in ALL cancer cell models through dCTP depletion.
DI-39 selectively inhibits the salvage (NSP) pathways. shows promising activity as a single agent and more prominently as combination therapy with other inhibitors of pyrimidine de novo synthesis in ALL cancer cells and mouse models.
Simultaneous targeting of dCK with the small molecule inhibitor DI-39 and RNR with thymidine (dT) in acute lymphoblastic leukemia (ALL) cancer cells induced replication stress and apoptosis confirming synergy between de novo dCTP inhibition and pyrimidine salvage inhibition.

物理化学性质&存储条件

分子量	524.67
分子式	C21H28N6O4S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(5-(4-(((4,6-diaminopyrimidin-2-yl)thio)methyl)-5-propylthiazol-2-yl)-2-methoxyphenoxy)ethyl)methanesulfonamide

参考文献

1. Laks DR, et al. Mol Cancer Ther. 2016 Jun;15(6):1271-8.