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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-Oroxylin A
Oroxylin A

Chemical Structure : Oroxylin A

CAS No.: 480-11-5

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Oroxylin A (6-Methoxybaicalein, Baicalein 6-methyl ether)

货号: PC-49421Not For Human Use, Lab Use Only.

Oroxylin A is a small molecule transketolase (TKT) inhibitor with SPR KD of 70.7 uM, inhibits hepatocellular carcinoma growth in vitro and in vivo.

规格 价格 库存 数量
25 mg ￥980 In stock
50 mg ￥1480 In stock
100 mg ￥2380 In stock
250 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Oroxylin A is a small molecule transketolase (TKT) inhibitor with SPR KD of 70.7 uM, inhibits hepatocellular carcinoma growth in vitro and in vivo.
Oroxylin A dose‐dependently decreased TKT protein levels after 48 h treatment in Hep1‐6 mouse hepatoma cells.
Oroxylin A not only inhibited TKT activity and expression, but also activated p53 signalling partially through targeting TKT.
Oroxylin A (0-100 uM) inhibits the growth of patient‐derived organoids.

物理化学性质&存储条件

分子量 284.267
分子式 C16H12O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one

参考文献

1. Jia D, et al. Clin Transl Med. 2022 Nov;12(11):e1095.

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