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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-Acelarin
Acelarin

Chemical Structure : Acelarin

CAS No.: 840506-29-8

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Acelarin (NUC-1031;NUC1031;NUC 1031;CPF-31)

货号: PC-42285Not For Human Use, Lab Use Only.

Acelarin (NUC-1031, CPF-31) is a gemcitabine phosphoramidate prodrug that can overcome the key cancer resistance

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Acelarin (NUC-1031, CPF-31) is a gemcitabine phosphoramidate prodrug that can overcome the key cancer resistance.
NUC-1031 is significantly less dependent on deoxycytidine kinase and on nucleoside transporters, and it is resistant to cytidine deaminase-mediated degradation compared with gemcitabine.
Acelarin (NUC-1031, CPF-31) inhibits L1210 and BxPC-3 cell proliferation with IC50 of 35 nM and 150 nM, respectively.
Acelarin (NUC-1031, CPF-31) significantly reduces tumor volumes in vivo in pancreatic cancer xenografts.

物理化学性质&存储条件

分子量 580.4744484
分子式 C25H27F2N4O8P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 36 mg/mL
Chemical Name/SMILES

L-Alanine, N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-, phenylmethyl ester

参考文献

1. Slusarczyk M, et al. J Med Chem. 2014 Feb 27;57(4):1531-42.

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