NSAH | Ribonucleotide reductase inhibitor | Probechem Biochemicals

Chemical Structure : NSAH

CAS No.: 1099592-35-4

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NSAH (Naphthyl salicylic acyl hydrazone, Ribonucleotide reductase inhibitor)

货号: PC-70217Not For Human Use, Lab Use Only.

Ribonucleotide reductase inhibitor NASH is a nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

Ribonucleotide reductase inhibitor NASH is a nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM.
NASH has twofold IC50 of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells.
NASH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells.

物理化学性质&存储条件

分子量	306.321
分子式	C18H14N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide

参考文献

1. Ahmad MF, et al. Proc Natl Acad Sci U S A. 2017 Jul 17. pii: 201620220.

NSAH (Naphthyl salicylic acyl hydrazone, Ribonucleotide reductase inhibitor)

生物&药学活性

物理化学性质&存储条件

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NSAH (Naphthyl salicylic acyl hydrazone, Ribonucleotide reductase inhibitor)

生物&药学活性

物理化学性质&存储条件

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