| Cat. No. |
Product Name |
Information |
| PC-42842 |
PD98059
MEK inhibitor
|
PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK. |
| PC-62664 |
Vacquinol-1
MKK4 activator
|
Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. |
| PC-62537 |
EBI-1051
MEK1 inhibitor
|
EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM. |
| PC-62503 |
E6201
MEK1/MEKK1 inhibitor
|
E 6201 (ER-806201) is a potent, selective, dual MEK1 and MEKK1 inhibitor, inhibits LPS-induced TNFα transcription with IC50 of 50 nM. |
| PC-62295 |
G573
MEK inhibitor
|
G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM. |
| PC-60589 |
PD184161
MEK1/2 inhibitor
|
PD184161 is a potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM. |
| PC-42216 |
APS-2-79 hydrochloride
KSR-MEK inhibitor
|
APS-2-79 hydrochloride is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM). |
| PC-42215 |
APS-2-79
KSR-MEK inhibitor
|
APS-2-79 is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM). |
| PC-42489 |
Mirdametinib
MEK inhibitor
|
Mirdametinib (PD0325901) is a selective, non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
| PC-44028 |
Refametinib
MEK1/2 inhibitor
|
Refametinib (BAY 86-97661, RDEA119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively. |
| PC-45504 |
Avutometinib
Raf/MEK inhibitor
|
Avutometinib (RO 5126766, CH5126766, VS-6766) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1. |
| PC-45828 |
CI-1040
MEK1/2 inhibitor
|
CI-1040 (PD 184352) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5. |
