PD184161 |CAS:212631-67-9 Probechem Biochemicals

Chemical Structure : PD184161

CAS No.: 212631-67-9

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PD184161 (PD 184161;PD-184161)

货号: PC-60589Not For Human Use, Lab Use Only.

PD184161 is a potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM.

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg	￥4680	In stock
100 mg		Get quote

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生物&药学活性

PD184161 is a potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM.
PD184161 inhibits HCC cell proliferation and induced apoptosis at concentrations of > or = 1.0 uM, significantly suppresses tumor engraftment and initial growth in tumor xenografts.
PD184161 also blocks AngII-driven HIF-1α protein in vascular smooth muscle cells, increases HIF-1α binding to von Hippel-Lindau tumor suppressor protein, blocks mitochondrial ROS production and cellular ATP levels.

物理化学性质&存储条件

分子量	557.6
分子式	C17H13BrClF2IN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide

参考文献

1. Klein PJ, et al. Neoplasia. 2006 Jan;8(1):1-8.

2. Yip-Schneider MT, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70.

3. Mazharian A, et al. Exp Hematol. 2009 Oct;37(10):1238-1249.e5.

4. Jalouli M, et al. Mol Pharmacol. 2017 Nov;92(5):510-518.

PD184161 (PD 184161;PD-184161)

生物&药学活性

物理化学性质&存储条件

参考文献

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PD184161 (PD 184161;PD-184161)

生物&药学活性

物理化学性质&存储条件

参考文献

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