Refametinib |CAS:923032-37-5 Probechem Biochemicals

Chemical Structure : Refametinib

CAS No.: 923032-37-5

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Refametinib (BAY 869766;BAY 86-97661;RDEA-119;RDEA119)

货号: PC-44028Not For Human Use, Lab Use Only.

Refametinib (BAY 86-97661, RDEA-119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg	￥3880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Refametinib (BAY 86-97661, RDEA-119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
Refametinib inhibits anchorage-dependent growth of human cancer cell lines harboring the gain-of-function V600E BRAF mutant with GI50 of 67-89 nM.
Refametinib exhibits complete suppression of ERK phosphorylation at fully efficacious doses in mice and orally bioactive.

物理化学性质&存储条件

分子量	572.3372
分子式	C19H20F3IN2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]-

参考文献

1. Iverson C, et al. Cancer Res. 2009 Sep 1;69(17):6839-47.

2. Chang Q, et al. BMC Cancer. 2010 Sep 28;10:515.

3. Schmieder R, et al. Neoplasia. 2013 Oct;15(10):1161-71.

Refametinib (BAY 869766;BAY 86-97661;RDEA-119;RDEA119)

生物&药学活性

物理化学性质&存储条件

参考文献

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Refametinib (BAY 869766;BAY 86-97661;RDEA-119;RDEA119)

生物&药学活性

物理化学性质&存储条件

参考文献

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