APS-2-79 hydrochloride |CAS:2002381-31-7 Probechem Biochemicals

Chemical Structure : APS-2-79 hydrochloride

CAS No.: 2002381-31-7

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APS-2-79 hydrochloride (APS 2-79 hydrochloride)

货号: PC-42216Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

APS-2-79 hydrochloride is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM).
APS-2-79 binds to the KSR2-MEK1 complex and impedes the assembly of RAF–KSR–MEK complexes, suppresses KSR-stimulated MEK and ERK phosphorylation and suppresses oncogenic Ras mutations.
APS-2-79 enhances the efficacy of Trametinib against cancer cell lines containing K-Ras mutations.

物理化学性质&存储条件

分子量	423.89208
分子式	C23H22ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO
Chemical Name/SMILES	4-Quinazolinamine, 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)-, hydrochloride (1:1)

参考文献

1. Dhawan NS, et al. Nature. 2016 Sep 1;537(7618):112-116.

APS-2-79 hydrochloride (APS 2-79 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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APS-2-79 hydrochloride (APS 2-79 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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