EBI-1051 |CAS:1801896-05-8 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-EBI-1051

Chemical Structure : EBI-1051

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EBI-1051 (EBI1051)

货号: PC-62537Not For Human Use, Lab Use Only.

EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM.
EBI-1051 shows superior potency in some cancer cell lines such as colon-205, A549 and MDA-MB-231 compared with AZD-6244.

物理化学性质&存储条件

分子量	504.228
分子式	C18H15F2IN2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1,3-Dihydroxypropan-2-yl)oxy)-7-fluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-5-carboxamide

参考文献

1. Lu B, et al. Bioorg Med Chem. 2018 Feb 1;26(3):581-589.

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EBI-1051 (EBI1051)

生物&药学活性

物理化学性质&存储条件

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EBI-1051 (EBI1051)

生物&药学活性

物理化学性质&存储条件

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