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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-PD98059
PD98059

Chemical Structure : PD98059

CAS No.: 167869-21-8

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PD98059 (PD 098059, PD-98059)

货号: PC-42842Not For Human Use, Lab Use Only.

PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK.
PD98059 prevents activation of MAPK and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells.

物理化学性质&存储条件

分子量 267.2793
分子式 C16H13NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 16 mg/mL; H2O: < 0.01 mg/mL
Chemical Name/SMILES

4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)-

参考文献

1. Dudley DT, et al. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7686-9.

2. Alessi DR, et al. J Biol Chem. 1995 Nov 17;270(46):27489-94.

3. Simon C, et al. Br J Cancer. 1999 Jul;80(9):1412-9.

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