| Cat. No. |
Product Name |
Information |
| PC-42489 |
Mirdametinib
MEK inhibitor
|
Mirdametinib (PD0325901) is a selective, non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
| PC-44028 |
Refametinib
MEK1/2 inhibitor
|
Refametinib (BAY 86-97661, RDEA119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively. |
| PC-45504 |
Avutometinib
Raf/MEK inhibitor
|
Avutometinib (RO 5126766, CH5126766, VS-6766) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1. |
| PC-45828 |
CI-1040
MEK1/2 inhibitor
|
CI-1040 (PD 184352) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5. |
| PC-42774 |
Trametinib
MEK1/2 inhibitor
|
Trametinib (GSK1120212, JTP-74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM. |
| PC-44036 |
RO4987655
MEK inhibitor
|
RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM. |
| PC-45572 |
BI-847325
MEK/Aurora inhibitor
|
BI-847325 is a potent, ATP-competitive MEK/Aurora kinase inhibitor, inhibts human Aurora A (IC50=25 nM) and Aurora C (IC50=16 nM). |
| PC-45849 |
Selumetinib
MEK inhibitor
|
Selumetinib (ARRY-142886, AZD-6244) highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1. |
| PC-27189 |
Arvenin I
MKK3 activator
|
Arvenin I is a plant natural product that activates T cells within the cancer-competitive environment, covalently reacts with and hyperactivates MKK3 (Mitogen-activated protein kinase kinase 3, MAP2K3), thereby reviving the mitochondrial fitness of exhausted T cells through the activation of p38MAPK pathway. |
| PC-25083 |
Polfurmetinib
MEK inhibitor
|
Polfurmetinib (Compound II) is a potent, selective mitogen activated protein kinase (MEK) inhibitor, displays an IC50 of 8 nM in human malignant melanoma A375 cells, inhibits ERK1/2 (Thr202/Tyr204) phosphorylation with IC50 of 2 nM. |
| PC-25048 |
Envometinib
MEK inhibitor
|
Envometinib (Compound 274) is a potent, selective dual MEK1/2 inhibitor, inhibits both pERK and pMEK in RAS mutant and NF-I loss of function (LoF) tumor models. |
| PC-24941 |
MKK4 inhibitor 39
MKK4 inhibitor
|
MKK4 inhibitor 39 is a potent, selective inhibitor of MKK (MEK4 or MAP2K4) with IC50 of 78 nM, 37-fold selective over RSK4 and high kinome selectivity. |
