MKK4 inhibitor 39

Chemical Structure : MKK4 inhibitor 39

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货号: PC-24941Not For Human Use, Lab Use Only.

MKK4 inhibitor 39 is a potent, selective inhibitor of MKK (MEK4 or MAP2K4) with IC50 of 78 nM, 37-fold selective over RSK4 and high kinome selectivity.

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250 mg		Get quote

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生物&药学活性

MKK4 inhibitor 39 is a potent, selective inhibitor of MKK (MEK4 or MAP2K4) with IC50 of 78 nM, 37-fold selective over RSK4 and high kinome selectivity.
MKK4 inhibitor 39 exhibits a selectivity score of 0.009 at 1 μM.
MKK4 inhibitor 39 exhibits robust target engagement in CETSA analysis.

物理化学性质&存储条件

分子量	353.36
分子式	C18H16FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((1-cyclopropyl-4-methyl-3-oxo-1,2,3,4-tetrahydropyrido[3,4-b]pyrazin-7-yl)amino)-3-fluoro-2-hydroxybenzonitrile

参考文献

1. Leon Katzengruber, et al. J Med Chem. 2025 Jul 11. doi: 10.1021/acs.jmedchem.5c00919.